Beilstein J. Org. Chem.2015,11, 837–847, doi:10.3762/bjoc.11.93
; proline-richpeptidesequences; Introduction
Multivalency is a general principle in nature for increasing the affinity and specificity of ligand–receptor interactions [1]. Multivalent binding is characterized by the cooperative, over-additive enhancement of binding affinities of ligands and receptors in
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Graphical Abstract
Figure 1:
Comparing the entropy loss during ligand–receptor interactions in dependence of the rigidity of the...